British Dental Journal

Warfarin has a half life of about 36 hrs, and it could take as much as 4 days for the INR to succeed in 1.5 once warfarin has been stopped depending on the unique INR worth. However, the INR decreases exponentially and has a wide interpatient variation in the speed of decrease.Sixty three When restarted, it takes about three days to achieve an INR of 2.0, such that patients might have at the least 2-3 days of subtherapeutic anticoagulation across the time of surgery.53 That is an particularly worrisome practice in patients which have had a thromboembolic event within the previous month. Since recurrent embolic events are extra frequent, and a few will probably be fatal, elective surgery must be deferred in this time period. Along with the danger of morbidity and mortality from thromboembolic events, the literature means that reducing the INR stage is costly and unnecessary from the standpoint of the likelihood of bleeding from dental procedures.1,38,50,55,64,65,66,67,68,69

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